Fertility preservation

What is fertility preservation?

The goal of fertility preservation is to assist patients in maintaining their fertility by preserving their eggs, sperm, embryos, or reproductive tissue so they can produce biological children in the future.

Fertility Preservation in lab
Reason Behind fertility - Best IVF Centre in Ahmedabad - Banker IVF

What are the reasons behind fertility preservation?

Medical reasons:

It is common knowledge that gonadotoxic cancer treatments like chemotherapy and radiation expose patients to a risk of subsequently becoming infertile. A few other conditions, such as endometriosis, autoimmune diseases, such as SLE and rheumatoid arthritis, and haematological disorders, such as thalassemia and aplastic anemia, frequently require therapy that could harm future fertility.

The gonadotoxicity of these treatments depends on a number of variables, including the patient’s age, ovarian reserve, the type of therapy (chemotherapy, radiation, immunotherapy, or surgery), as well as the doses and duration of that therapy. Thus, for all of these women or couples, fertility preservation is crucial.

All patients who have a condition that may affect their ability to conceive in the future or who require treatment that could be gonadotoxic are offered counselling.

Social reasons:

When a couple want to postpone getting married or having children but does not have a specific medical condition, they can choose to freeze their eggs, sperm, or reproductive organs. There could be many potential causes for the postponement, including career, financial security, or any other social factor.

This is more crucial for women because over time, the quantity and quality of eggs decrease, which may cause issues when trying to conceive later on. Early egg or embryo freezing ensures better quality, which is beneficial for the couple.

Who needs fertility preservation?

Males with following conditions require fertility preservation:

Couples is consulting with dr. Manish Banker about IVF treatment

Married women with following conditions require fertility preservation:

Unmarried women / girls with following conditions require fertility preservation:

What are the treatment options available?

Treatment options for men

Fertility in adult males can be maintained via cryopreservation of mature spermatozoa. It is the most popular and well-known approach for an adult male. Cryopreservation should ideally be carried out before beginning cancer treatment.

Masturbation is used to gather sperm samples. One sample of semen can only be utilized for one attempt at pregnancy, hence it is best to collect and store several samples.

Invasive surgical methods, such as TESA/micro-TESE, etc., can be utilized to collect spermatozoa in patients with low sperm counts. Sperm is typically stored for a duration of ten years. Sperm cells are used to fertilize the ovum using assisted reproduction (intracytoplasmic sperm injection), which results in the development of an embryo.
Invasive surgical procedures like TESA, PESA, micro-TESE, etc. can be utilized to retrieve spermatozoa in patients with a low sperm count or in males who are unable to produce an ejaculate.

Sperms retrieved by testicular biopsy in this manner are maintained. When spermatozoa are obtained and cryopreserved prior to chemotherapy, it is helpful for cancer patients.

These may be applied to fertilize oocytes and produce embryos following cancer treatment or whenever the couple is prepared.
Although still in the experimental stage, this choice may hold promise for prepubescent males. Prior to receiving cancer therapy, testicular tissue and Spermatogonial stem cells [SSCs] are cryopreserved.

Seminiferous tubules are implanted with SSCs made from frozen testicular tissue. It goes through self-renewal and establishes spermatogenesis, which should enable natural conception without the need for additional reproductive treatments.

Treatment options for women

Women who are unmarried, post pubertal girls (adolescent girls whose periods have begun), or those without a long-term spouse should use this approach.

The European Society of Human Reproduction and Embryology recommends it as the best strategy for preserving fertility because it has a long history of success.

Oocyte retrieval and controlled ovarian stimulation are used to accomplish this. Cryopreserved mature eggs (metaphase stage, Mll oocytes) are collected. Using ART/IVF, frozen eggs are thawed later and fertilized.

This method is also effective for married women whose partners are away from home for an extended amount of time.

It is one of the best & established method for fertility preservation in a married couple.

Partner availability is a must for embryo freezing method. It requires ovarian stimulation, followed by egg retrieval, fertilization, & cryopreservation of the embryos.

Frozen embryos can be stored for up to 5 years. A frozen embryo transfer can be done at any time when the couple is ready.

It is a newer technique for overcoming anticancer treatment delays.

Immature eggs are obtained trans-vaginally, where they are then matured in a specific medium. Mature eggs can then be cryopreserved, or if a partner is available, an embryo can be created through ART and frozen.

The benefit of this approach is that chemotherapy and radiation therapy can be started right away.
It is an experimental option. For women who are unable to postpone treatments like radiotherapy or chemotherapy, this may be an alternative.

Throughout the menstrual cycle, it is possible at any time. Because it involves surgery, general anesthesia is necessary.

With this technique, either the entire ovary or the ovarian cortex containing the primordial follicles can be cryopreserved. After the patient’s therapy is finished, the cryopreserved tissue is thawed and put back into the body.

Due to the age-related decline in ovarian reserve, it should ideally be performed on young women. Following transplantation, ovarian endocrine function typically lasts for about 5 years.

Depending on the type of cancer, there is a small risk that ovarian tissue transplantation will reintroduce malignant cells.
Navigate through our other treatments